The two sides played out a turgid 0-0 draw in the initial tie at Valley Parade two weeks ago, and Championship outfit Reading will start as favourites to progress.
Only once before have Reading reached the semi-finals of this famous competition, when they were beaten by 3-0 by Cardiff City in 1927.
The timing of the replay - just 48 hours after both clubs were in action in their respective leagues - has been criticised by many.
Reading boss Steve Clarke made nine changes to his side on Saturday for a 4-1 defeat at Watford, while Bradford's team for a 1-1 draw with Notts County showed six alterations.
"I don't think it [facing Arsenal] makes any difference whatsoever," he said.
"I think the game against Bradford is big enough in its own right and the reward of going through to an FA Cup semi-final is big enough in its own right.
"The home crowd are important. It's amazing how much the home support give the players a lift. It's something in football that's underrated."
Reading come into the game 17th in the Championship with just one win in their last five league outings, and Clarke said five players - whom he refused to identify - missed the trip to Watford with injury.
City boss Phil Parkinson, a popular former player at Reading, has his sights set on a first semi-final for Bradford since they won this competition in 1911.
"For me personally, it will obviously be special to go back to Reading - I have a lot of fond memories from my time there - but obviously the main focus is on the prize of playing Arsenal in the FA Cup semi-finals," he said.
"We are really looking forward to this one. We will have a meeting with the staff in the hotel on Sunday night to decide what team we will pick for what will be an unbelievable occasion.
"I'm sure it will be a cracking atmosphere around the ground on Monday night and we can't wait for it."
