Roberto Martinez's men have racked up three wins and two draws on their own turf in the Premier League this season, and three points at the weekend would see them move level with their local rivals.
Everton head into the fixture looking to extend a four-match unbeaten run in the top flight, although their last two games have both produced 0-0 draws.
Successes over Hull City and Aston Villa were followed by stalemates against Tottenham and Crystal Palace, and Martinez will hope for a better performance in front of goal as they aim to improve their league position of sixth.
The Spaniard takes charge of his maiden Merseyside derby after joining the club in the close-season, and the 40-year-old believes the fact the two sides are so closely matched in the table heightens the game's importance.
"I am delighted to be getting ready for a first Merseyside derby and really looking forward to it," he said. "When you add all the connotations of a derby with the importance of the points, I think this fixture is going to be as big and good as a football game can be."
A Fernando Amorebieta own goal and a strike from Martin Skrtel established a two-goal cushion, before Luis Suarez's double completed the comfortable victory.
Liverpool's last defeat to Everton came in a 2-0 reverse at Goodison Park in October 2010, with strikes from Tim Cahill and Mikel Arteta settling the game on that occasion.
Brendan Rodgers' men lead the head-to-head record between the sides with 88 wins to 66, although last season's fixtures both produced draws.
