Huddlestone ended an eight-year stay with Tottenham to join Hull on a permanent deal in August and has impressed during the latter's strong start to the season.
Fellow midfielder Jake Livermore also made the move from London to the KC Stadium on a season-long loan but is not eligible to face his parent club.
While Livermore will miss out, Tottenham's Gylfi Sigurdsson is wary of the threat provided by former colleague Huddlestone.
Sigurdsson told his club's official website: "Tom is a fantastic player as we all know. I saw at first-hand last season just how good he can be.
"His passing and vision is unbelievable and if we allow him too much time, he will find his targets and cause us damage.
"He and Jake have done really well for Hull and I'm sure their performances are one of the reasons why they have made a decent start to the campaign."
Andre Villas-Boas made seven changes for his side's UEFA Europa League meeting with Sheriff on Thursday - which Tottenham won 2-0 through goals from Jan Vertonghen and Jermain Defoe - and can be expected to shuffle his pack again.
Indeed, with several players – including Livermore, Allan McGregor (thigh), Sone Aluko (calf) and Danny Graham (knee) – unavailable, Bruce has claimed Hull could struggle to name a full allocation of substitutes.
