Arsenal will be desperate to stop their former talismanic striker, who scored 37 goals for the Gunners in all competitions last term before joining United in August where he has continued to find the net ahead of the Old Trafford clash.
The Londoners, though, had no trouble without him on Tuesday when they sealed a remarkable 7-5 extra-time win at Reading in the League Cup after trailing 4-0 at one stage in an extraordinary match.
"I always said that he will be a striker, so we are on the same wavelength there," Wenger told reporters having struggled to replace Van Persie.
"Secondly, I believe he knows where to be in the box on the rebounds. I like that - that's a quality of a striker that you cannot give to anybody. You feel it or you don't."
The last time United scored as many as seven in a game was August last year when they beat Arsenal 8-2 at home but they have netted consistently this season, losing Wednesday's League Cup last 16 clash 5-4 at Chelsea after extra time.
Arsenal are sixth while United will start Saturday's Premier League encounter in second after their controversial 3-2 win against leaders Chelsea last Sunday in the first of two back-to-back games between the sides.
United raced into a quickfire 2-0 lead at Stamford Bridge last Sunday with an own goal from David Luiz after four minutes and Van Persie's ninth goal of the season eight minutes later.
Chelsea clawed the score back to 2-2 before Javier Hernandez's offside winner for United in a match which encapsulated United's season so far - strong in attack and fragile at the back.
"From a spectator's point of view it was a terrific game of football. You're getting your money's worth with nine goals, there's no doubt about that," United manager Alex Ferguson said. "We only have ourselves to blame, really."
After losing to United, Chelsea accused match referee Mark Clattenburg of using "inappropriate language" to Nigerian John Obi Mikel.
