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Rooney missed Saturday's trip to Norwich City after suffering a recurrence of the groin problem that saw him sit out the League Cup quarter-final against Stoke City earlier this month.
But the Premier League champions are confident that the 28-year-old will be in contention to make an immediate return when Tottenham head north to Old Trafford on Wednesday.
"Wayne Rooney didn't travel to Norwich due to the recurrence of a groin strain. He should be available for #mufc vs @SpursOfficial on 1 Jan," confirmed United via the club's official Twitter account.
Rooney, on target in the 3-2 win at Hull City on Boxing Day, is United's top scorer this season with 11 goals in all competitions.
