Drulovic has assumed temporary charge after Sinisa Mihajlovic resigned in November following Serbia's failure to qualify for this year's FIFA World Cup.
Serbia finished third in UEFA qualifying Group A after taking 14 points from their 10 games, with Croatia claiming the play-off place ahead of them.
A disappointing defeat to minnows Macedonia ultimately proved crucial in ending Serbia's hopes, but Drulovic will look to bring back some of the feel-good factor against a Republic of Ireland side who will also be watching the World Cup from home.
Drulovic rose to prominence when he guided Serbia's Under-19s to success at the 2013 European Championships in Lithuania, and the country's football association are hoping he can achieve similar things with the senior team - even if on a temporary basis.
"This is the best possible solution because Drulovic has earned his chance after achieving the historic success of winning the European Under-19 title last year," the Serbian Football Association said upon announcing Drulovic's appointment.
And the 45-year-old has already stamped his own mark on the side, recalling Roma midfielder Adem Ljajic to the national set-up after almost two years in the international wilderness after he was dropped by Mihajlovic for failing to sing the national anthem.
He is joined in the squad by Twente's Dusan Tadic, who represents a significant goal threat after netting 11 times in 25 Eredivisie matches so far this term.
Their failure to qualify for the World Cup ended Giovanni Trapattoni's reign, although their have been encouraging early signs under new boss Martin O'Neill and his assistant Roy Keane.
O'Neill's side have been drawn alongside three-time European champions Germany in Group D, along with Poland, Scotland, Georgia and debutants Gibraltar.
Serbia's task is no less challenging, with Denmark, Portugal, Albania and Armenia also in Group I.
The two previous meetings between these sides have ended in draws, but O'Neill is set to be without a number of players through injury as Ireland aim to buck that trend.
Richard Dunne has also withdrawn, with the defender being rested by his club - although O'Neill insists he could still play a part in the qualifying campaign for the Euros.
"If the qualifying campaign (started) in the morning, because of the amount of games he has played and the form he has shown for Ireland over quite a number of matches, you would certainly have to give (his selection) consideration," said O’Neill, who called up QPR goalkeeper Brian Murphy on Monday.
