Carlo Ancelotti's men are brimming with confidence after defeating Barca in the final of the Copa del Rey.
That was swiftly followed by an excellent 1-0 triumph over reigning European champions Bayern in Wednesday's UEFA Champions League semi-final first leg at the Bernabeu.
Now the attention turns to the league and the club's attempt to overhaul rivals Atletico Madrid, who currently top La Liga and have a six-point cushion over third-placed Real, albeit having played a game more.
However, the Liga giants will need no reminding of the danger posed by Javi Gracia's men following a 2-2 draw in the reverse fixture in December, a game that saw Real come from two goals down and both teams finish with 10 men.
The forward is La Liga's top goalscorer with 28 goals and team-mate Fabio Coentrao believes his availability further boosts Real.
"Any team would love to have Cristiano Ronaldo, the best player in the world," he told the club's official website.
"It is a privilege to play with him and we made good combinations."
Osasuna's recent form can be best described as mixed. Gracia's charges are unbeaten in four, but have won just once in nine league matches.
