Lyon and Valencia endured frustrating opening games in Champions League Group H and will seek to kick-start their qualification bids at Stade de Gerland on Tuesday.
Hubert Fournier's men were held 1-1 by a Gent side who had two players sent off - with Alexandre Lacazette missing a late penalty - while the Liga outfit suffered a 3-2 home loss to Zenit.
That was during a memorable era for Valencia, who reached back-to-back Champions League finals at the turn of the century and won La Liga in 2001-02 and 2003-04.
But Nuno Espirito Santo's charges have failed to impress domestically so far in this campaign and their last four games have yielded only one win.
The five-goal thriller against Zenit was in stark contrast to Valencia's top-flight matches, where there have only been five goals in six games.
Only Malaga have scored fewer in La Liga, but Valencia do boast a defensive record better than every side except Real Madrid.
Valencia have already enjoyed some success against Ligue 1 opponents this season, having beaten Monaco over two legs to qualify for the competition proper. Indeed, in their last 11 away matches against French sides, Valencia have lost only twice.
Their one foray into the semi-finals, in 2009-10, ended with a 4-0 aggregate drubbing at the hands of Bayern Munich.
Valencia will be without defender Jose Gaya (hamstring) and goalkeeper Matthew Ryan (knee), while Lyon's injury woes see the likes of Nabil Fekir (knee) Rafael (thigh) sidelined.
