The 40-year-old has been appointed as the boss of Eredivisie side Heerenveen, signing a two-year contract with the club, who are set for a midtable finish when the Dutch season ends this weekend.
Van Persie had previously been in charge of Feyenoord's under-18s side, the side where he began and ended his playing career.
"I would like to continue my development and the role of head coach fits in perfectly with that goal," said Van Persie.
"Heerenveen is a very nice Premier League club with a rich tradition and loyal supporters.
"It is a fantastic challenge to contribute to the sporting ambitions and development of the club as head coach."
Van Persie replaces Kees van Wonderen in the Heerenveen dugout, after he announced he would be stepping down this summer back in March.
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As a player, Van Persie signed for Arsenal for just £2.75million in 2004, winning the Community Shield and FA Cup in his first season in north London and while no more honours would follow during his time with the Gunners, he scored 132 goals during his eight years with the club.
A controversial £24million move to Manchester United followed in 2012, with Van Persie helping to fire the Red Devils to what remains their last Premier League title in 2012/13.
He closed his playing career out with stints at Fenerbahce and Feyenoord, while on the international front he remains the Netherlands' all-time leading goalscorer with 50 goals in his 102 appearances and played in the 2010 World Cup final defeat to Spain.
For more than a decade Joe Mewis has worked in football journalism as a reporter and editor, with stints at Mirror Football and LeedsLive among others. He is the author of four football history books that include times on Leeds United and the England national team.
