A draw would give the Rossoneri a nine-point lead over second-placed Inter Milan, who could only match their rivals' tally with wins in the three remaining games starting with a home match against Fiorentina on Sunday.
As goal difference does not count in Serie A and the head-to-head record of the two teams is used, Milan can be crowned champions for the first time since 2004 given they beat Inter in both fixtures this term.
"You talk about the scudetto only when it is sewn on to the shirt," an unusually coy club owner Silvio Berlusconi told Italian television before reverting to his confident self.
"If we succeed, it will be the 27th trophy won under my ownership. After me, the club president who has won the most trophies was the great Bernabeu at Real Madrid and the Spaniards named the stadium of their capital after him."
Winning the title after such a long wait for a European giant will make the triumph extra special for Massimiliano Allegri's side while the fact they are set to end Inter's five-year stranglehold on the scudetto makes it sweeter for Milan fans.
Inter are also bossed by last season's Milan coach Leonardo, adding another twist to Italy's championship race.
Interim boss Vincenzo Montella is also trying to convince the board to keep him on with more impressive performances like last weekend's last-gasp 3-2 win at Bari where captain Francesco Totti surpassed Roberto Baggio's tally of 205 Serie A goals to stand fifth on the all-time scoring list.
If Milan do win or draw, the championship presentation is not expected to be held at Rome's Stadio Olimpico but instead they will wait for the San Siro home game against coach Allegri's former side Cagliari on May 14.
At the other end, second-bottom Brescia need to beat Catania at home on Sunday to make sure they survive for another weekend while Sampdoria's city derby with Genoa could be crucial to their hopes of avoiding the drop.
