Arsenal are currently in the driving seat for the final UEFA Champions League qualification spot, although a run of five consecutive wins has seen Everton move to within four points of their visitors with a game in hand.
That means another victory this weekend would put Roberto Martinez's side in control of their own destiny, with Arsenal's challenge faltering due to a return of just 13 points from their last 10 Premier League outings.
And Martinez, who is without captain Phil Jagielka (hamstring) and Steven Pienaar (knee), believes his side will have added motivation for the crucial clash following their Cup exit.
"The game we played in the quarter-final of the FA Cup left us with a sour taste," said the Spaniard. "And we need to make sure we use Sunday's game to perform as well as we can.
"It (the result) could have a huge bearing (on who finishes fourth).
"We are fighting with a direct rival that we admire and respect, and are in this position every season - they find a way to perform in these big games."
"It's an opportunity to go forward and as well an opportunity to make a distance with Everton," Wenger said.
"Everton are a good side, that's why they are where they are.
"For us it's very difficult to imagine the impact it will have on finishing fourth, but it's a game we want to win."
However, Kieran Gibbs (ankle) and Serge Gnabry (knee) are doubtful, while Jack Wilshere (foot) and Mesut Ozil (hamstring) are definitely out.
