PSG were knocked out of the Europa League on Thursday, despite a 4-2 win against Athletic Bilbao, while Lille were eliminated from the Champions League group phase last week.
Both teams, however, are on a three-match winning streak and have high hopes of challenging for the league title.
"I expect a big reaction and a victory against Lille," said coach Antoine Kombouare after the Athletic game.
His Lille counterpart, Rudi Garcia, said: "We must beat Paris. We showed [against Dijon last Sunday] that we had turned the Champions League page.
"We have a solid team, we won three in a row and we haven't lost in our last 15 [league] games, so it shows our rivals we are in the mix."
A return to home turf is good news for Rene Girard's side, the best team at home this season, who hope to bounce back from last weekend's unexpected 1-0 defeat at Valenciennes.
