Arsenal trio Alexis Sanchez, Danny Welbeck and Tomas Rosicky are among the players left out of the club's 27-man squad for the Asia Trophy.
Sanchez and David Ospina are both missing following the Copa America, which was won by the former's Chile.
"Calum [Chambers] has decided to shorten his holiday and come back on Friday," Wenger told Arsenal.com. "He didn’t play in the under-21s and needs preparations.
"Welbeck isn't completely recovered from the problem he had [at the end of last season]. He's not back in full training so he will stay behind.
"Rosicky will stay back because he got a small injury at his last game against Iceland with Czech Republic.
"Ospina is on holiday until July 27 and Alexis is on holiday until August 3. Serge Gnabry is on holiday after playing with the under-21s. He's back on July 20."
