It was far from a classic Juventus performance, with the absence of Serie A top scorer Carlos Tevez to injury clearly felt by the visitors, who had goalkeeper Gianluigi Buffon save a second-half penalty.
Tevez's replacement, Pablo Daniel Osvaldo, had two goals ruled out for offside during a tame first half, and Juve looked on the verge of just their second league loss this season when Arturo Vidal was adjudged to have handled in the penalty area with 19 minutes left.
Buffon was Juventus' hero though, as he has been so many times throughout his illustrious career, comfortably saving a weak effort from Napoli loanee Emanuele Calaio.
Juventus' latest victory sees them move 17 points clear of the second-placed Roma, who host Udinese on Monday.
Juventus – who brought in Giorgio Chiellini after Andrea Barzagli was injured in the warm-up – were not at their fluent best in a first half dominated by Osvaldo's bad luck.
Ex-Juventus forward Giuseppe Sculli fired over in the sixth minute before Osvaldo was denied with his side's first real chance.
Sebastian De Maio's attempted clearance hit Fernando Llorente and fell to the Southampton loanee, who dinked over goalkeeper Perin and then tapped in, only to see the offside flag raised.
After the interval, Bertolacci showed great skill to beat Chiellini before thrashing an effort at Buffon, who was relieved to see Marco Motta's rebound go wide.
But Buffon was up to the task as substitute Calaio's tame effort to the right was comfortably saved.
