The Spaniard spent a turbulent six months at the Milan outfit in 2010 before he was relieved of his duties by former owner Massimo Moratti and returns for the first time on Saturday, when both sides have European qualification in mind.
Benitez has cemented Napoli's place in the top three in his first season at the club and can guarantee UEFA Champions League football this weekend.
If Napoli can match, or better Fiorentina's result against Bologna they will be assured of a place in the qualifying rounds next season, while Inter are on course to seal their spot in the UEFA Europa League.
Inter are unbeaten in five games and if they can extend that to six against Benitez's side, then they will fancy their chances of securing a European spot.
The 32-year-old Argentina international, Inter's leading scorer, knows they will have to be at their best in order to extend their unbeaten run.
"We have Napoli, another difficult match, and it is important for us to put in a great performance to try to qualify for the Europa League," he told Inter's official website.
"We're looking good at the moment and I think we're having a decent season."
