De Gea, 22, who has been called up before but has yet to make an appearance for the world and European champions, has been brought in as cover for injured captain Iker Casillas and will compete for the keeper's spot with Liverpool's Pepe Reina and Victor Valdes of Barcelona.
De Gea has come in for some criticism since moving to Old Trafford from Atletico Madrid for around 20 million euros in 2011, with his slight build cited as a weakness.
Manager Sir Alex Ferguson has stood by him, however, and praised the Spaniard after a fine performance in United's Champions League last 16, first leg at Real Madrid last month.
There was no place in Del Bosque's 24-man squad for misfiring Chelsea striker Fernando Torres or Bayern Munich midfielder Javi Martinez.
Torres's Chelsea team-mate Cesar Azpilicueta, Manchester City midfielder Javi Garcia and Malaga playmaker Isco were included as Del Bosque continues his policy of promoting younger players while maintaining an experienced base.
"We are bringing the players who deserve to be here," Del Bosque told a news conference at the Spanish football federation (RFEF) headquarters outside Madrid.
"It's our goal to continually inject new blood into the team," he added.
"We will have time to see in what condition the three keepers are when they arrive, three great keepers."
