The Group C clash in Piraeus will pit the Ligue 1 champions against the Greek Super League winners, and although PSG will be heavy favourites, it is easy to forget that they have little Champions League experience as a club.
PSG will take heart from the fact they reached the quarter-finals last season though, as they enjoyed a successful campaign that saw them win their first Ligue 1 title in 19 years.
And to compound Blanc's misery, defender Alex suffered a thigh injury in training on Saturday that will rule him out of this fixture.
Experienced Champions League outfit Olympiacos will be hoping to improve on last season's performance, when they were knocked out in the group stages.
After a busy close-season, Olympiacos' squad is barely recognisable to last year's, with Javier Saviola and Vladimir Weiss heading the arrivals.
Only eight players registered by Olympiakos for last season's group stage will be involved in the competition this season.
Olympiacos have started their league campaign in superb fashion, winning all four matches, with Konstantinos Mitroglou's six goals helping them to the top of the table.
But they will face a very different test on Tuesday as Blanc's PSG come to town expecting a result.
