Germán Denis Lautaro Acosta, Jose Sand, German Denis, Alejandro Silva and Nicolas Pasquini were on target in Lanus' 5-0 rout of visiting Zulia.
The Strongest and their hopes of reaching the final stages will go down to the wire, while Atletico Nacional remain perfect.
Sao Paulo kick-started their Copa Libertadores, while Huracan sealed a vital win over Sporting Cristal.
Sporting Cristal secured a 3-2 win at home to Huracan while Atletico Nacional proved too strong for Penarol in a 2-0 victory.
Atletico Nacional shot three points clear at the top of Group 4 after their big win over Sporting Cristal, while Huracan saw off Penarol.
Pumas UNAM secured an entertaining 4-2 result over Emelec, while Penarol and Colo Colo managed 1-1 draws away from home.
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