Vicente del Bosque, coach of European and world champions Spain, told Spanish television that the 26-year-old will play in the February 6 friendly against Uruguay in Doha.
Michu will be joined in the Spain squad by Iago Aspas, currently being linked to Swansea, whose manager Michael Laudrup is an admirer of the Celta Vigo forward.
"Iago Aspas and Michu will appear [against Uruguay]," confirmed Del Bosque.
Michu has been prolific since his bargain $3.2 million transfer from Rayo Vallecano in the summer, topping the Premier League scoring charts with 13 goals in 18 games.
He leap-frogged Manchester United's Robin van Persie after scoring the equaliser in Sunday's 1-1 home draw against the league leaders.
Aspas may well be on Laudrup's wish-list for the January transfer window but the expected price tag of around $13 million could put Swansea off.
Get the best features, fun and footballing frolics straight to your inbox every week.
Thank you for signing up to Four Four Two. You will receive a verification email shortly.
There was a problem. Please refresh the page and try again.