Suarez has scored 28 goals in just 25 top-flight appearances this season to help Liverpool into second place in the table, only four points behind leaders Chelsea with a game in hand.
Tottenham's next Premier League fixture sees them travel to Anfield on Sunday, with Vertonghen set to be handed the unenviable task of keeping Suarez - and his strike partner Daniel Sturridge, who has 19 Premier League goals this term - at bay.
And the Belgian, who played with Suarez at Ajax, believes his former team-mate is the main reason Liverpool are nine points clear of Tottenham in the standings.
"Suarez, Suarez is the reason for that (points difference)," Vertonghen said.
"At the moment he is up there as one of the best strikers in the world. I think he is the difference between the teams.
"They are one of the best teams in the league and they show it every week.
"It is going to be very hard, especially at Anfield, and I hope we can play as we did last season because we did very well, not the result but the performance."
Liverpool won the reverse fixture at White Hart Lane 5-0 back in December - a game that marked the end of Andre Villas-Boas' time in charge of Tottenham.
Get the best features, fun and footballing frolics straight to your inbox every week.
Thank you for signing up to Four Four Two. You will receive a verification email shortly.
There was a problem. Please refresh the page and try again.