After four meetings last season - including a tight League Cup semi-final settled on away goals - this weekend will present the first opportunity for the clubs to butt heads in 2019/20.
Over the years, this clash has served up goalfests aplenty: 4-2 results in 2017 and 2012, a 5-3 in 2015, a 4-0 in 2014, and even a 4-4 back in 2008.
But which stars are responsible for those high-scoring fixtures? In today's quiz, we want you to name the last 50 goalscorers in games between these two sides – a challenge that will take you back to March 2007, when Chelsea were a good third place and Spurs a poor 11th.
There are 10 minutes on the clock for you to get all 50 – so let @FourFourTwo know your scores, and see where you end up on our daily Twitter leaderboard.
THEN TRY… QUIZ! Can you name every Arsenal player with 10+ Premier League goals?
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