Third-tier Championnat National side Chambly sprung a major Coupe de France shock in the round of 64 as Wilfried Louisy-Daniel fired a first-half hat-trick to help sink Ligue 1 club Reims 4-1.
Olivier Guegan's men will turn their attention back to a relegation scrap having been humiliatingly put to the sword by Louisy-Daniel, who had two goals inside nine minutes and headed home to complete an astonishing treble before the interval.
Worse was to come as Youcef Touati added a fourth three minutes after the restart and Reims' misery was long established by the time Nicolas de Preville scored a penalty one minute from time.
Troyes needed extra-time to see off Dunkerque 4-3, with Jessy Pi the hero for Ligue 1's bottom club.
Toulouse were Ligue 1's most comfortable winners on Saturday, brushing aside Entente SSG of National 2 5-0 as Denmark international Martin Braithwaite scored a goal in each half.
High-flying Angers were 3-1 winners over Racing Besancon – Ismael Traore settling the nerves with a sixth-minute opener before Cheikh N'Doye and Charles Diers made the tie safe.
Elsewhere St Malo overcame Avranches on penalties after the match finished 1-1, Concarneau beat TA Rennes 3-0 and Stade Montois of the fourth tier won 1-0 at the Championnat National's Rodeo.
