After three rounds of competition, PSG enter the Coupe de la Ligue at the last 16 stage as they make the trip to the Stade Francois Coty for their fixture against Ajaccio on Wednesday.
Form is no issue for PSG leading into their midweek trip, with the French champions unbeaten in Ligue 1 - one point adrift of leaders Marseille.
"Thiago needs to get his confidence back, after a tough World Cup. He hasn't lost his qualities overnight, and he knows that," Blanc told PSG's official website.
"It's also up to me to ensure he gets his confidence back. The coaching staff, the other players and myself will do everything we can to ensure he gets back to his best as quickly as possible."
PSG upstaged Lyon 2-1 in last season's final, with Edinson Cavani's first-half brace doing the damage at the Stade de France.
Lyon - third in the league standings - can count on home comforts to help get them over the line, having won eight consecutive matches at the Stade de Gerland following Saturday's 3-0 win over Caen.
"We are happy with a job well done," coach Hubert Fournier was quoted as telling Lyon's official website.
"It was an important match to continue our excellent run at home against a potentially dangerous opponent."
