Vicente del Bosque's men, who became world champions with a 1-0 extra-time victory over Netherlands at Soccer City in Johannesburg, will be looking to end 2013 on a high after the year produced their first loss in a competitive match since that tournament.
It was Brazil, hosts of the 2014 competition, who inflicted that defeat in the final of the Confederations Cup, but Spain have since won five of the last six matches, qualifying for next year's tournament as winners of their group.
A much-changed Spain were far from their fluent best in Malabo but goals from Santi Cazorla and Juanfran proved enough for the visitors.
Gordon Igesund's men failed to qualify for the World Cup as they were eliminated in the second round of CAF qualification after finishing second in their group behind Ethiopia.
South Africa's next competitive priority will be to reach the finals of the 2015 Africa Cup of Nations, but of immediate concern is the task presented to them by the number-one ranked nation.
Kaizer Chiefs striker Bernard Parker should provide South Africa's main attacking threat after scoring five goals in their qualification campaign.
