The leaders were well in control against Lille last week after taking the lead in the third minute at Stade Pierre Mauroy but two second-half goals ended their 11-match unbeaten league run.
Next up is a Montpellier side still with serious ambitions of a European place, and coach Hubert Fournier has challenged his team to be more solid defensively.
He told Lyon's official website: "We have to have a good look at what went wrong in that second half [against Lille] and prepare for our trip to Montpellier. We need to be more consistent and less fragile at the back."
Sunday's clash is the second game in a run of three in a row away from home for Lyon, but Fournier's men have shown good form on their travels so far this term, losing just four times in the league away from their own ground.
That run includes draws at Monaco and Paris Saint-Germain, although they do have a number of injury concerns heading into the weekend's clash.
Marcelo Bielsa's Marseille lie three points behind PSG in third and take on 18th-placed Toulouse on Friday without suspended duo Rod Fanni and Brice Dja Djedje.
Elsewhere, Saint-Etienne are looking to arrest a worrying run of results with victory over Lorient on Sunday, while Willy Sagnol's Bordeaux travel to Caen 24 hours earlier knowing that a win could catapult them into fourth place.
