Defending champions PSG travel to the Stade Louis II five points clear of Monaco at the top of the table and can take another step towards securing a second straight title by extending that lead with victory over the principality club.
The capital club have suffered just one defeat in the league this campaign, a 2-0 loss at Evian in December, but face a difficult challenge if they are to maintain that record against a Monaco side that is superb in front its home fans.
A PSG triumph would be severely damaging to Monaco's already fading title hopes, but Laurent Blanc's men will have to achieve that without club-record signing Edinson Cavani, who misses out through a thigh injury sustained in last Friday's 2-0 win over Bordeaux.
The Uruguay striker joins Monaco's star recruit Radamel Falcao on the sidelines after the Colombia international that suffered a knee ligament injury last month.
Falcao was on target in the reverse fixture at the Parc des Princes back in September, cancelling out Zlatan Ibrahimovic's opener in a 1-1 draw, but PSG should be favourites to claim the points in his absence.
Ibrahimovic will likely be key if PSG are to earn a first league win over Monaco since 2007 after the Sweden striker took his tally for the season to 31 with a double on Tuesday as Blanc's side clinched a place in the Coupe de la Ligue final by winning 2-1 at Nantes.
Defender Aymen Abdennour (thigh) is out, but midfielder Jeremy Toulalan returns from suspension and Ricardo Carvalho is back after missing last Saturday's 2-2 draw with Lorient through illness.
