Elie Baup was sacked as Marseille coach after their loss to Nantes on Friday and sporting director Jose Anigo has been named caretaker boss.
Fifth in Ligue 1, Marseille face a side sitting just two places below them on the table in the Coupe de France.
Fourth-placed Nantes meet top-flight battlers Nice and Bastia will face Evian TG in other ties.
The only other all-Ligue 1 battle is between Rennes and relegation-battling Valenciennes, who are five points from safety.
Ligue 1 leaders Paris Saint-Germain travel to second-tier Brest, Monaco visit Vannes and Lille face a trip to Amiens.
‘Arteta, Alonso, Emery, me… none of us were physical players – we needed the understanding of the game. That probably helped us move into management’: Premier League boss reveals reasons for natural career progression
‘England have the players to win the World Cup – it’ll be tough for Thomas Tuchel to do a bad job, with the squad he has at his disposal’ Former Three Lions winger backs new boss after gentle qualifying draw
