Uruguay's Luis Suarez opened the scoring in the 48th minute, taking the ball to the right of the area before easily going by two defenders and beating Russia goalkeeper Vyacheslav Malafeyev with a low drive from 12 metres.
Second-half substitute Alexander Kerzhakov equalised a minute later, taking advantage of a defensive miscue as the Latin Americans appealed for offside.
"We played against a very good team, which is ranked number three in the world by FIFA," Russia coach Dick Advocaat told a news conference.
"Uruguay have four strikers in their team whose average price is 40 million [euros]. But we played well today and we're going in the right direction," he said.
"I think we haven't shown our full potential just yet, the most important thing is to improve for our first Euro 2012 game against the Czech Republic."
Friday's match was the last test for the Russian players to impress Advocaat before the Dutchman announced the final 23-man Euro 2012 squad later in the evening.
"You want to know the starting keeper and the rest of our line-up? Well, you'll see it when we take to the pitch against the Czechs," Advocaat told reporters.
