Group A leaders Inter have seven points from three matches and can seal qualification with two games to spare with victory at White Hart Lane. However, a draw would probably be an acceptable result for them against second-placed Spurs (four points) with a home game against Twente Enschede next up.
One thing Inter coach Rafa Benitez will have been working on is how to stop Gareth Bale after the Spurs wide man scored a marauding hat-trick to almost bring his side level despite playing most of the match with 10 men after the sending off of goalkeeper Heurelho Gomes.
"Bale played a great game," Inter president Massimo Moratti said after his stunning treble.
"In the past we have tracked him but now he's worth an awful lot more. We were a bit shocked by that Tottenham comeback."
Bale's travelling interest remains a little closer to home at the moment as, when the 21-year-old Wales international was given a few days off last week, he chose to spend them visiting his family in Cardiff.
Midfielder Rafael van der Vaart, suspended for the San Siro game and probably his team's most influential player this season, went off with what looked like a hamstring injury late in that match and could be doubtful for Tuesday.
Inter will also probably be fielding their second-choice keeper as Julio Cesar suffered a thigh strain in Friday's battling 1-0 win at Genoa.
The Genoa game was also a very rare occasion this season where red-hot Samuel Eto'o has not netted but he is likely to carry the goalscoring burden again on Tuesday given Diego Milito and Goran Pandev were only fit enough for the bench on Friday.
"I've said the team can improve by 30 percent but determination and character are the base for any improvement. We've got to be a bit more incisive," said the Spaniard.
