The Spanish side are bottom of Group A with two games remaining and they must secure all three points at the Donbass Arena and hope Manchester United beat Bayer Leverkusen to avoid crashing out of Europe's premier club competition.
Jagoba Arrasate's charges picked up their first point by holding United to a 0-0 draw last time out and they will be out for revenge against the Ukrainian champions, who beat them 2-0 in San Sebastian back in September.
Arrasate will be concerned by his side's form on their travels, however, as they have only won once on the road in the Spanish top flight this term to go with their 2-0 Champions League play-off win at Lyon in August.
Mircea Lucescu's side have drawn their two home games in the group, but they will also come into the game on the back of an impressive victory, having beaten Sevastopol 4-0 at the weekend to cement top spot in the Ukrainian Premier League.
