The two teams have never met in competitive action, but go head to head in the first leg of the last 32 with Juve looking to avenge their recent disappointment at the hands of another Turkish side.
Antonio Conte's men were knocked out of the UEFA Champions League in the group stages as Super Lig champions Galatasaray progressed instead after a 1-0 winner-takes-all victory against Juve in the final Group B game.
Gala held Juve to a 2-2 draw in Turin earlier in a group stage campaign that saw Conte's side earn just one victory, which came against minnows Copenhagen.
Juve's exit from the Champions League came as a surprise, however the Serie A leaders will now be focused on extending their pedigree in the second-tier competition.
However, their domestic campaign has been less fruitful and they head into the clash without a permanent manager after Mustafa Resit Akcay's resignation earlier this month.
A 4-2 defeat to Akhisar Belediyespor prompted Akcay's decision to step down, with assistant Hami Mandirali taking temporary charge of a side who are ninth and without a Super Lig win in four games.
Juventus are set to be without defender Giorgio Chiellini due to a thigh injury, while striker Mirko Vucinic is unavailable with a knee problem.
