The uncapped 19-year-old Varane picked up a muscle injury during Real Madrid's 1-0 defeat at Granada in la Liga on Saturday.
"Real Madrid and France doctors agreed that the player was not fit enough to play in the coming days," a statement read.
The 23-year-old Yanga-Mbiwa, who joined Newcastle from Montpellier during the transfer window, has three international caps.
Thank you for reading 5 articles this month* Join now for unlimited access
Enjoy your first month for just £1 / $1 / €1
*Read 5 free articles per month without a subscription
Join now for unlimited access
Try your first month for just £1 / $1 / €1
Get the best features, fun and footballing frolics straight to your inbox every week.
Thank you for signing up to Four Four Two. You will receive a verification email shortly.
There was a problem. Please refresh the page and try again.