Once Caldas' first loss of the Colombian Primera A season led to Deportes Tolima climbing to the top of the table.
Alianza Petrolera's 1-0 win at home to Once Caldas opened the door for Deportes Tolima, whose draw against Atletico Nacional was enough to send them top.
Alberto Gamero's Deportes Tolima moved a point clear after the 1-1 draw at home.
Despite the hosts being on the back foot through the first half, Davinson Monsalve put them ahead with a scrappy goal following a corner in the 40th minute.
A powerful 51st-minute penalty from Edwin Cardona saw 10th-placed Atletico Nacional take a share of the spoils.
At Alianza Petrolera, David Valencia headed in the game's only goal in the 18th minute against Once Caldas.
The hosts managed to hold on despite a 33rd-minute red card to Jonathan Avila.
Second-placed Aguilas Doradas claimed their third win in four games as Edison Palomino scored a second-half brace in a 2-0 victory at Fortaleza.
At the other end of the table, La Equidad remain without a point after a fourth straight loss, beaten 3-2 at Uniautonoma.
The win was Uniautonoma's first of the season and came thanks to a brace from Michael Barrios.
Winless Deportivo Pasto sit on three points after another draw, this time a 1-1 result at Millonarios.
Boyaca Chico came from behind to draw 2-2 at Envigado and Atletico Huila finished their 4-1 loss at Medellin with nine men.
Patriotas Boyaca's hosting of Junior finished goalless and Deportivo Cali beat Santa Fe 2-0.