The league will go on a six-week hiatus before matches resume on January 30, offering players a chance to recharge after a gruelling start to the 2014-15 campaign.
Bayern are 11 points clear of Wolfsburg at the Bundesliga summit, unbeaten after 16 rounds so far.
Pep Guardiola's men have played a total of 25 games in all competitions following Tuesday's 2-0 Bundesliga win at home to second-bottom Freiburg.
That is without mentioning the World Cup in Brazil, which saw a number of Bayern's players lift the trophy with Germany.
"It'll be important to win in Mainz as it's our last game before Christmas," Manuel said.
"We've invested a lot of energy in the last few weeks and months so we really have to win it.
"I don't really think about how many goals I'm going to concede, we really just do take it game by game. In the first half of the season I think we've played really well and been very successful."
Wolfsburg are back on home soil against 10th-placed Cologne after they came from behind twice to earn a 2-2 draw at Borussia Dortmund on Wednesday following Naldo's 85th-minute equaliser.
"Both sides played well. When you're 2-1 down it's a point gained. Considering how the game unfolded, we have to be content with the draw," Diego Benaglio said afterwards.
"You always need a bit of luck. We had that [against Paderborn] but we also worked hard," said Eric Maxim Choupo-Moting, who scored Schalke's equaliser.
