Guingamp, who put relegation concerns aside last season to win the 2014 showpiece at the expense of Rennes, were drawn against Yzeure in January following their respective victories.
The Coupe de France holders saw off Ligue 2 side LB Chateauroux 2-0 in the round of 32, while Yzeure upstaged second division team Valenciennes by the same scoreline.
Guingamp are yet to face Ligue 1 opposition en route to the last 16 as they prepare for Wednesday's trip to Stade de Bellevue but Jocelyn Gourvennec's men head into the fixture full of confidence following Sunday's impressive 1-0 win at home to Monaco.
"Our victory was a huge accomplishment because it was a very strong team we were up against anyway, never mind playing 10 against 11," Gourvennec said afterwards.
"We lost to them in the Coupe de la Ligue three weeks ago. Despite that result, losing a man in that game showed us that we could against them 10 against 11.
"I think Monaco struggled, even though they had some chances and Jonas [Lossl] made some really important saves."
PSG's form leading into Wednesday's match at Parc des Princes is strong, having won three of their past four fixtures in all competitions, which includes Sunday's 1-1 draw at Ligue 1 leaders Lyon.
"We deserved to win tonight, but luck wasn't on our side. We played well. We played some good football," PSG midfielder Blaise Matuidi said on Sunday.
"We were up against an excellent goalkeeper and he should be congratulated. We didn't do what we needed to do to open the scoring."
Christophe Galtier's Saint-Etienne are away to third-tier Red Star.
