The Germany international has not played for Dortmund since March 19, when he sustained the injury in Dortmund's UEFA Champions League last-16 second leg against Zenit.
However, the 26-year-old returns to Dortmund's squad for the visit of Markus Gisdol's men.
"Marcel Schmelzer will be back and hopefully Erik Durm," Klopp said at his pre-match press conference.
Klopp's charges are guaranteed to finish second in the Bundesliga this term, having amassed 65 points with two matches remaining.
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