In the past 12 months, Romania have won five out of seven encounters on home soil, beating the likes of Belgium and Australia, who will be at next year's tournament in Brazil.
A double from Konstantinos Mitroglou sandwiched an effort from Dimitris Salpingidis in Athens on Friday, Romania's away goal - which could prove crucial - coming courtesy of Bogdan Stancu.
"Of course - in theory - we have the best chance to qualify, especially after we won the first match with a two-goal difference," said the Greece forward.
"However, the distance between winning and losing is very small, especially in big football games.
"We have to be careful in Bucharest; we have an extremely difficult mission there."
Victor Piturca is without his captain Vlad Chiriches due to the defender's broken nose.
