Wigan enjoyed their finest hour last May when Ben Watson's late header at Wembley earned the Lancashire club a stunning 1-0 victory over big-spending City to lift the famous trophy for the first time, before being brought down to earth when they were relegated from the Premier League a matter of days later.
City have already thrashed their local rivals 5-0 in the League Cup earlier this season and the two sides lock horns once again at the Etihad Stadium on Sunday in the quarter-finals of the FA Cup this Sunday.
Manuel Pellegrini's side added one trophy to their cabinet last weekend when they beat Sunderland 3-1 in the League Cup final and can move a step closer to winning another by making it a miserable return to the club for Wigan manager Uwe Rosler.
The German was a big fans' favourite during his playing days at City, scoring 50 goals during a four-year spell at the club in the 1990s.
Rosler, who was named manager of the month for February on Friday, said: "My first reaction (following the draw) was to ban all talk of that game. We started talking about this game this week. It was important to focus on the league.
"We go into the game with no pressure whatsoever. The pressure lies on City. We already achieved a wonderful cup run. Being in the sixth round of the FA Cup has only happened in the third time in the history of the football club.
"And doing that on the back of last year's win made it even more special. We overcame big hurdles and now the hurdle is very big, but that also means there is a great challenge in front of us, for me as a manager, but also for my players to measure yourself against world-class players."
City boss Pellegrini will have one eye on Wednesday's UEFA Champions League last-16 clash at Barcelona, when his side have the major task of trying to overturn a 2-0 deficit from the first leg.
