La Liga leaders Barcelona will make the trip to Seville on Saturday, with plenty on the line for both teams.
Barcelona are four points clear of arch rivals Real Madrid with eight fixtures remaining after routing Almeria 4-0 midweek, while Sevilla sit one point behind Valencia in the race for the fourth and final UEFA Champions League spot, which seals qualification into the play-off round, following their 2-1 win at Levante.
Luis Enrique's Barca have registered six successive away victories in the league this season, while they have only tasted defeat twice in total - against Real Sociedad and Real.
Carrico acknowledges beating Barca will be an uphill task but the Portuguese is counting on Sevilla's home form to help the club over the line, with the UEFA Europa League champions in the midst of a 26-match unbeaten streak in front of their supporters, which stretches back to February last year.
"Beating Barca is very difficult; they're the league leaders, but people know that whoever comes to the Sanchez Pizjuan won't have it easy," Carrico told reporters on Thursday.
"[We will] try to make life difficult for Barca, try to keep a clean sheet and hit them on the break.
"The game on Saturday is complicated but playing in front of your fans always helps a lot."
Cristiano Ronaldo, James Rodriguez and Toni Kroos will miss the match at The Santiago Bernabeu after accumulating five yellow cards for the season during Wednesday's 2-0 victory at Rayo Vallecano.
Real have decided to appeal Ronaldo's contentious booking, however, after the Portugal captain was cautioned for simulation.
"The coach makes his decisions for the best of the team," Casillas said.
"This is something that we all accept. The important thing is to win and hope that Barca slip-up. It's nothing to do with protection."
