PSV lead on goal difference from Twente with 37 points after 17 matches at the halfway point of the season, four ahead of third-placed Groningen who beat Vitesse Arnhem 4-1 on Friday.
Ajax Amsterdam, held to 1-1 draw by visitors NEC Nijmegen, slipped to fourth spot with 32 points.
Twente's Dutch international Theo Janssen scored either side of the break with curling free-kicks around the wall to earn a 2-0 victory over Graafschap as his side warmed up for the visit of Tottenham Hotspur in the Champions League on Tuesday.
Lacklustre Ajax took the lead against NEC through Mido's header 14 minutes from time but just two minutes later the Amsterdam side's defence failed to clear a free-kick from Lasse Schone and that gave Bram Nuytinck the chance to equalise.
