The Old Trafford outfit head into Tuesday's encounter against the Germans ready to compete at the business end of the Champions League for an 18th successive season, and with their sights set on a fourth title.
But although it is business as usual for the Premier League champions, the match represents new territory for Moyes.
And he will start his bid with very little European experience to draw on, having only enjoyed the briefest of forays into the competition in the past when his Everton side were knocked out of the third qualifying round by Manuel Pellegrini's Villarreal in 2005.
In terms of his selection plans, Moyes faces a dilemma over the fitness of Wayne Rooney, after the England striker played the full 90 minutes of United’s 2-0 win against Crystal Palace on Saturday wearing a special headband to protect a head wound that ruled him out of international duty.
Meanwhile, in the opposing dugout on Tuesday will be a fellow rookie in the competition in the shape of Sami Hyypia, a former player of United’s Premier League rivals Liverpool and a winner of this trophy as a player with the Anfield club back in 2005.
He was part of the side, led by Rafael Benitez, that came from 3-0 down to beat Milan on penalties.
Their new-look squad appears to have gelled well as they sit in third place in the Bundesliga after five matches, with Hyypia once again likely to look to in-form duo Sidney Sam and Stefan Kiessling to lead their charge, with both having scored four times already this campaign - including in Saturday's 3-1 win over Wolfsburg.
