Africa has emerged as major source of talent, with players such as Liberian-born Weah, Didier Drogba and Samuel Eto'o playing for some of Europe's leading clubs.
And while an African team had never advanced beyond the quarter-finals of a World Cup, Weah said the 2010 tournament could change that.
"We hope for that, it's not impossible. It's a difficult task but it's not impossible," Weah told reporters. "Ghana just won a junior world cup. Why not?"
Ghana won the under-20 World Cup last month.
Speaking to reporters after a news conference, Weah, who won European and World player of the year in 1995, said discipline and hard work were the keys to success.
"Years ago, we couldn't partake in the best player of Europe and the world. It happened. There is a high possibility that an African team can win a World Cup if it can prepare well."
Weah hoped that the new stadiums being built for the World Cup and the African Cup of Nations in Angola next year would lay the foundations for stronger African football.
"I'm sure all of the infrastructure they leave here will give people jobs, allow children to play in stadiums that are being built," he said.
"A lot of kids don't have opportunity to play on grass."
