Paris Saint-Germain's record 36-match unbeaten run in Ligue 1 was brought to an end when they lost 2-1 to Lyon.
Bruno Genesio's hosts led by two at the break after Maxwel Cornet's slick early strike was followed up by a wonderful individual goal from Sergi Darder.
Laurent Blanc's men remain firmly on course to defend their title, but any hopes of going the whole top-flight campaign without defeat and extending a run without losing that began in March 2015 are at an end.
Lyon had been defeated by PSG four times this season – in the reverse Ligue 1 fixture and in three cup competitions – but move up to third place with a triumph that extends their unbeaten run to five games at their new stadium, Parc Olympique Lyonnais.
Caen's hopes of a shock qualification for the Champions League were boosted with a 2-1 win away at one of their many rivals for a top-three place, Saint-Etienne.
Ronny Rodelin's left-footed strike capped a swift counter-attack as the visitors made it two, meaning Valentin Eysseric's stoppage-time free-kick was a mere consolation for Saint-Etienne.
Just two points separates third-placed Lyon from Caen, Nice, Rennes, Saint-Etienne and Nantes – who sit eighth – in the thrilling race for the Champions League.
The match between Gazelec Ajaccio and Marseille was postponed due to the effects on the pitch of two days' heavy rain.
