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The draw was made on Thursday, with Yzeure rewarded for their victory over Ligue 2 outfit Valenciennes with a visit from the holders.
French champions Paris Saint-Germain, meanwhile, will host fellow Ligue 1 side Nantes after battling their way past Bordeaux on Wednesday.
The only other all top-flight affair will come at the Stade Louis II, where Monaco are set to entertain either last season's beaten finalists Rennes or Reims.
The ties are scheduled to take place on March 10.
