Pescara coach Giovanni Stroppa, in charge for only 13 games, became the fifth coaching victim of the season after his side missed a penalty and had two players dismissed in a 1-0 defeat to fellow strugglers Siena.
Four players were sent off, three of them from Palermo, and two penalties were awarded as hosts Bologna beat the Sicilian side 3-0.
"I can say that for three games in a row, we have had to deal with refereeing injustices, which have prevented us from getting the result," he said.
Two goals from Alberto Aquilani helped Fiorentina thrash Atalanta 4-1 in Florence to go third. Gonzalo Rodriguez and Luca Toni also scored as the hosts, a far cry from last season's struggling outfit, chalked up their fifth win in a row.
Genoa were desperately unfortunate to concede a second when goalkeeper Sebastien Frey saved Mauro Icardi's drive at the near post, only for the ball to ricochet on to team-mate Cesare Bovo and into the net from six metres.
Genoa, who had won five of the last six derbies, pulled one back through Ciro Immobile in the 73rd minute and nearly equalised before teenager Icardi celebrated his Serie A debut by restoring Sampdoria's two-goal lead.
Genoa's sixth defeat in a row left them bottom with nine points while Sampdoria climbed to 14th with 13 points.
Palermo, who have won only twice this season, had goalkeeper Samir Ujkani, midfielder Edgar Barreto and substitute Carlos Labrin dismissed in the second half while Bologna's Saphir Taider was also given his marching orders.
"I am absolutely not going to change the coach," Palermo p
