Inter Milan striker Samuel Eto'o is out of the joint leaders' trip to Genoa on Saturday because of a foot injury, the Serie A champions said in a statement.
Coach Jose Mourinho may be forced to play Mario Balotelli up front alone with former Genoa forward Diego Milito also out with a hamstring problem, although David Suazo is another option.
Injured midfielder Thiago Motta is another Inter absentee for the visit to his old club.
Genoa midfielder Houssine Kharja has been ruled out for six months after rupturing his cruciate knee ligaments, the club website said.
Former Inter striker Hernan Crespo is fully fit, however.
Juventus, who have not won in four, hope to have midfielder Mohamed Sissoko available for the first time since he broke his foot in March when they host Fiorentina on Saturday.
Alessandro Del Piero and midfielder Claudio Marchisio miss out through injury.
Fiorentina will be buoyed by striker Alberto Gilardino's hat-trick in Italy's 3-2 win over Cyprus on Wednesday.
Marco Marchionni and Cristiano Zanetti are likely to face their former side with ex-Juve striker Adrian Mutu also pushing for a start after spending much of the season on the bench.
AC Milan resume their stuttering campaign at home to AS Roma on Sunday with under-pressure coach Leonardo likely to opt for a 4-4-2 formation, media reports have said.
Defender Oguchi Onyewu is out for four months after injuring his knee when the United States drew 2-2 with Costa Rica on Wednesday.
Roma striker Francesco Totti is battling to be fit after a knee problem.
New Napoli coach Walter Mazzarri could be without forward Ezequiel Lavezzi for Sunday's home game against Bologna with media reports saying the Argentine has lost his passport and has been unable to return from international duty.
Napoli have only said that Lavezzi has not yet come back.
