Roberto Martinez's men recorded a 4-0 home win over Stoke on November 30, courtesy of goals from Gerard Deulofeu, Seamus Coleman, Bryan Oviedo and Romelu Lukaku.
The Merseyside club have claimed 13 points out of a possible 18 since that match and will begin 2014 in fourth, having lost just twice in the Premier League this season - the fewest defeats of any top-flight team.
Glenn Whelan and Marc Wilson were both dismissed as Stoke were beaten 5-1 at St James' Park, while Stephen Ireland and Andy Wilkinson were forced off at White Hart Lane during Sunday's 3-0 reverse.
Jagielka joins Deulofeu (hamstring), Arouna Kone and Darron Gibson (both knee) on the sidelines, but Martinez was able to select Antolin Alcaraz and Leighton Baines for Sunday's 2-1 win over Southampton after both men returned to full fitness.
Everton's home form has gained much attention, with the club's surprise defeat to Sunderland on Thursday representing their first loss at Goodison Park since December 2012.
Martinez has fond memories of Stoke's home, though, having celebrated top-flight survival there with former club Wigan Athletic on the final day of the 2010-11 season.
