According to BBC Sport, Spurs have bid £53 million for Lo Celso.
The 23-year-old was reportedly a target for Manchester United and Real Madrid.
After the young midfielder struggled to make an impact at the Parc des Princes, the La Liga club triggered their €22 option to buy him in April.
Lo Celso now has a €100m release clause in his contract and it's believed that Betis want closer to that amount for the player.
Christian Eriksen is linked with a move to Real Madrid, and it's thought that Spurs may be lining up a replacement for the creative Dane.
Regardless, any deal would see Lo Celso become Spurs' most expensive signing ever, smashing the £42 million they spent on Davinson Sanchez in 2017.
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