Hoffenheim fell to their third defeat in four Bundesliga games as two stoppage-time strikes from Werder Bremen ensured they triumphed 3-1 at the Rhein-Neckar-Arena.
Eduardo Vargas had cancelled out Zlatko Junuzovic's first-half opener as the hosts looked set to claim just their second point of the season, only for Anthony Ujah to snatch a winner late on.
And Junuzovic rubbed salt in the wound with another goal from an acute angle to compound Hoffenheim's woes.
In Sunday's other fixture, Schalke bounced back from a draw with Darmstadt and a defeat to Wolfsburg to beat Mainz 2-1 at the Veltins Arena, despite Klaas-Jan Huntelaar's early missed penalty.
Schalke took the lead in the 37th minute as Joel Matip headed home from a Johannes Geis corner, but the sides went into the break level with Yunus Malli equalising three minutes ahead of the interval after Christian Clemens had rattled the post.
As a result Schalke move up to fifth position, one place above Bremen, while Mainz sit 10th and Hoffenheim are just above the relegation play-off place.
