As well as missing the suspended Lionel Messi and Sergio Busquets, Barcelona will be without full-back Eric Abidal who picked up a groin injury while on international duty with France, for Saturday's game at home to strugglers Sporting Gijon.
Abidal will be sidelined for some 10 days, Barca said on their website. Midfielder Thiago Alcantara was a doubt for Saturday due to a problem with his right tibia sustained on duty with Spain, they added.
"We have to try and not lose any more and wait for Madrid to drop points to cut into their lead," Pedro, whose season has been disrupted by injury, told a news conference on Thursday.
"We won't give up on this title and we'll fight until the end."
"There is such a big gap between the top two and the rest that two players being out is almost anecdotal," he was quoted as saying in an interview with Sport daily published on Friday.
"When a team has 70 percent possession it's almost an obligation for them to win," the 61-year-old added.
Jose Mourinho's Real side host eighth-placed Espanyol on Sunday amid fresh speculation that the Portuguese coach is set to move on at the end of the season after he was photographed in London and British media reported he was house hunting.
"I have no idea," Real captain Iker Casillas was quoted as saying when asked about Mourinho. "I don't know what every person will or won't do. Nobody knows what can happen."
Espanyol's Ivory Coast midfielder Ndri Romaric has tasted victory at the Bernabeu with his previous club Sevilla and is convinced the Barcelona-based side can boost their Champions League qualification hopes with a win at Real.
"In football we all know that it is possible to win," he was quoted as saying in Friday's edition of As. "We will be faithful to our philosophy and we will go there without fear."
Levante, who host Real Betis on Monday, occupy Spain's fourth Champions League qualification place, five points behind third-placed Valencia, who play at Granada on Sunday.
